New paper alert! A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

Hot off the presses, here’s an exciting collaborative project involving researchers from the University of British Columbia, Aarhus University, Scripps Institution of Oceanography, and the University of Florence. Working together, we show strong evidence that vacuolar-type H+-ATPase and plasma-accessible carbonic anhydrase in the vascular structure supplying the retina act together to acidify the red blood cell leading to O2 secretion. In vivo data indicate that this pathway primarily affects the oxygenation of the inner retina involved in signal processing and transduction, and that the evolution of this pathway was tightly associated with the morphological expansion of the inner retina. We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive evolution of vision in teleost fishes.


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