Four new papers!

Characterization of Type-II ionocytes within the saccular epithelium. Figure 4, Kwan et al. 2020.

If you’re seeking some fascinating reading to keep you company during COVID-19, look no further! Like many of you, our lab is closed during the pandemic (for now) but we’re all still keeping busy at home by finishing up those pesky manuscripts we’ve been procrastinating on. Enjoy!

First, our newest postdoctoral researcher, Garfield Kwan, just published “Immunological characterization of two types of ionocytes in the inner ear epithelium of Pacific Chub Mackerel (Scomber japonicus).” This paper discusses the cellular mechanisms responsible for endolymph ion regulation and otolith formation, and can helps contextualize responses to environmental stressors such as ocean acidification.


Second, our lab came together to write a review on the “Evolutionary links between intra‐ and extracellular acid–base regulation in fish and other aquatic animals.” This review summarizes some of the distinct acid–base homeostatic mechanisms that have evolved in aquatic organisms to meet the particular challenges of this environment.

Cellular localization of sAC in S. pistillata. Figure 4, Barott et al. 2020.


Third, in collaboration with researchers at UPenn and the Centre Scientifique de Monaco, we conducted a study on the “Regulation of coral calcification by the acid-base sensing enzyme soluble adenylyl cyclase.” Our results indicate that sAC activity modulates some of the molecular machinery involved in producing the coral skeleton, which could include ion-transporting proteins and vesicular transport.




Finally, we recently published a new book chapter entitled “CO2 and Acid-Base Sensing” in Fish Physiology. This chapter synthesizes our knowledge concerning the sensory pathways that allow fish to sense acid-base disturbances of both metabolic and environmental origin and the ensuing downstream physiological responses that promote homeostasis in different organs.